dear all,
i really really need help with this one...
i'm doing some research about one injection product, composition of the product is amidopyrin and methampyronum.
all i want to ask is when i try to make the product, the colour of product is mostly yellow (not clear) (once i try and the colour is clear, only once). my friend said that the product colour must be clear not yellow (becoz if the colour yellow, mean that the product is already toxic). my question is :
1. is that true when the colour already yellow, so that the product already toxic?
2. what the root cause of this (yellow colour)? coz i've search all over the web there no answer....i think its becoz that nobody produce this anymore....
3. what should i do to prevent this product become yellow?

thanks waiting for reply...
truly....really need help with this one...:(
thanks:thanx:

I have asked several Covers knowledgeable about medical matters to assist.

I will try to help from a purely chemical processing perspective. Frequently chemical reactions depend on the ratio of ingredients or outside factors such as the temperature of the reaction. If our medical experts cannot assist you, consider designing an experiment (DOE) where you vary the ratio of ingredients. See mixture experiments at NIST (http://www.itl.nist.gov/div898/handbook/pri/section5/pri54.htm) or Statsoft (http://www.statsoft.com/textbook/stexdes.html#mixturef). Included in the experiment should be processing factors such as temperature.

..................... composition of the product is amidopyrin and methampyronum.........................

If you correct the spelling as: amido pyrin and methampyrone, you may be able to find out more.

Synthesis and anti-inflammatory activity of a series of mono- and ... (http://www.google.com.my/url?sa=t&source=web&ct=res&cd=1&url=http%3A%2F%2Fwww.springerlink.com%2Findex%2FGP0T708VR1410V05.pdf&ei=vwqySsKtJcyjkAWM-MjcCw&rct=j&q=amido+pyrin+%2B+methampyrone&usg=AFQjCNEETGFb22ZucCEeYxN_UJkc1OQpuw)

The Cove is a great resource, but I can't even imagine basing a toxicity-related human-use pharma manufacturing decision on uncredentialed advice.

I don't work in pharma, but I would think that would be wholly beyond proper acceptable practice.

My recommendation would be that you need assistance that is more formally authoritative than what can be provided in a public forum.

My recommendation would be that you need assistance that is more formally authoritative than what can be provided in a public forum.:applause:Great reminder. Otherwise, we could solve the quest for exothermic nuclear fusion sustainable process here.

:applause:Great reminder. Otherwise, we could solve the quest for exothermic nuclear fusion sustainable process here.

I'm working on that right now. :tg:

dear all,
i really really need help with this one...
i'm doing some research about one injection product, composition of the product is amidopyrin and methampyronum.
all i want to ask is when i try to make the product, the colour of product is mostly yellow (not clear) (once i try and the colour is clear, only once). my friend said that the product colour must be clear not yellow (becoz if the colour yellow, mean that the product is already toxic). my question is :
1. is that true when the colour already yellow, so that the product already toxic?
2. what the root cause of this (yellow colour)? coz i've search all over the web there no answer....i think its becoz that nobody produce this anymore....
3. what should i do to prevent this product become yellow?

thanks waiting for reply...
truly....really need help with this one...:(
thanks:thanx:

Are these names "brand names" for the two materials ? If yes, pl give generic names of the materials as that will help get more directed responses.

Are these names "brand names" for the two materials ? If yes, pl give generic names of the materials as that will help get more directed responses.

Part of the problem is that the OP misspelled the two chemicals. It should be methampyrone and aminopyrine. Apparently, the former is a derivative of the latter:

Methampyrone (n.)

1.(MeSH (http://www.nlm.nih.gov/mesh/MBrowser.htm))A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE. Because of the risk of serious adverse effects its use is justified only in serious situations where no alternative is available or suitable. (From Martindale, The Extra Pharmacopoeia, 30th ed, p13)Link (http://dictionary.sensagent.com/methampyrone/en-en/)
The above description indicates that the prior advice to not seek information about such things in Internet forums (especially those not related to pharmaceuticals) should be heeded.

dear all,
i really really need help with this one...
i'm doing some research about one injection product, composition of the product is amidopyrin and methampyronum.
all i want to ask is when i try to make the product, the colour of product is mostly yellow (not clear) (once i try and the colour is clear, only once). my friend said that the product colour must be clear not yellow (becoz if the colour yellow, mean that the product is already toxic). my question is :
1. is that true when the colour already yellow, so that the product already toxic?
2. what the root cause of this (yellow colour)? coz i've search all over the web there no answer....i think its becoz that nobody produce this anymore....
3. what should i do to prevent this product become yellow?

thanks waiting for reply...
truly....really need help with this one...:(
thanks:thanx:

The discoloration from clear to yellow would happen in an aqeous solution, right ? This happens in many compunds which are salts of the compound. But being discolored doers not mean that there is a loss of potency.

Methampyrone is a drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE. Because of the risk of serious adverse effects its use is justified only in serious situations where no alternative is available or suitable. Read HERE (http://www.wrongdiagnosis.com/medical/methampyrone.htm)

Btw, I have moved your post in the Pharmaceuticals section to get more specific answers :)

:topic:
Sorry, pet peeve time - clear and colored (yellow in this case) are not mutually exclusive. Something can be both clear and yellow.

I'm assuming you want something clear and colorless.

I will try to help from a purely chemical processing perspective. Frequently chemical reactions depend on the ratio of ingredients or outside factors such as the temperature of the reaction.

And the substrate being used. Is this an aqueous reaction or are organic solvents involved in the synthesis?