Defining Safety Precautions for Category 4,5 Molecules

v9991

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Categorization of molecules is depending on OEL values 'occupational exposure levels'
OEL = [(NOEL) x (human body weight)]/[(safety factor)n x (human breathing
rate)],
* NOEL is typically in units of milligram of chemical administered/kilogram of animal body weight/day;
* Human body weight typically is assumed to be 70 kiligrams for an adult male;
* Safety factors for accomodating limitations in the data, as described above; and
* Breathing rate in workers typically is assumed to be 10 m 3/8-hour workday.
{ Occupational health categorization and compound handling practice systems— roots, application and future

Occupational Exposure Bands (OEBs)

}

controls are proportionate to the oels (obviously increasing towards category 1--> 5)

my question is...
can we additionally factor the activity-exposure risks/levels to calibrate the controls.
viz., a powder handling having maximum controls (viz., dedicated-controlled environments), and
once solubilized, once it enters the liquid state, reducing the levels of controlled environments!

can this approach of activity-exposure-levels/risks to harmones' 'cytotoxic products' etc
 

v9991

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The approach of 'proportionate controls' with respective risk-exposure levels is appropriate.

final criteria would be 'compliance to legal/regulations' from respective geography. it is noted that agencies are usually open to engage a debate on the 'risk / rationale of stated approach'; and other may not be so.

hence, it all depends on the authority on other side of desk, to accept/allow the proposed approach!!! (that is a huge uncertainity and risk!)
 

Marc

Fully vaccinated are you?
Leader
Sorry no one answered your question.

Thanks for stopping back and updating this thread with what you found. We all appreciate it!
 
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