I am confused as to whether or not approval signature(s) must be on every page of a document in an facility under ISO 13485 and 21 CFR. There is no requirement in either regulation but I know of someone whom said they mediated between FDA and a company - the company made approval signatures on every page. The issue of approval signatures here is in regard to issuance of a revised and new document. How do you handle approval signatures? Every page or on one area?