Clinical study

Aymaneh

Registered
#1
Hello everyone,
Clinical studies can be separated into two main categories: monocentric studies carried out at a single recruitment center and multicentric studies involving several centers.
Why do we often prefer a multi-center study to a single-center study?
is there any specific requirements on what type of study should be carried out ?

Thank you in advance
 
Elsmar Forum Sponsor

Raisin picker

Quite Involved in Discussions
#2
The separation you mention is just one of many, and, in my opinion, not an important one. You have exploratory vs. confirmatory studies, blinded vs. open, ...

To answer your question, a multi-center study hase some advantages:
  • reduced bias due to more investigators
  • faster recruitment
  • larger/more varied subject base (especially when in different regions/countries)
  • attach more investigators to the product (think of key opinion leaders, conferences, publications, ...)
  • reduced risk of failure when one investigator is suddenly not available anymore (due to accident or other job; seen both)
Of course, it is more expensive due to increased travel cost, requires more monitoring, more irb boards and even CAs involved etc.
 
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