This question comes up fairly often, especially the "wearing many hats" issue. It can be done. One of the best answers I have seen came from a Q&A page:
MYTH: "Accreditation will require more personnel resources."
FACT: Personnel involved in quality assurance procedures will vary based upon the size of the laboratory. Larger laboratories may require personnel dedicated to working within a quality system, whereas smaller laboratories may not require dedicated personnel. Even in larger laboratories, some personnel may perform multiple roles. This does not necessarily create a conflict of interest. The personnel resources for maintaining accreditation are less than the initial investment of obtaining accreditation. There are successful approaches for small and one-person laboratories to implement quality systems.