With zero repeats and all terms (factors plus all interactions) included in the model, all degrees of freedom are used and MSE cannot be calculated. You must pool non-significant factors to create this.
In your case, I recommend taking the higher order (4-way and 3-way) interactions (AxBxCxD, AxBxC, AxBxD, etc,) out of the model. This will create an MSE.
You could remove the four-way interaction first, and run the analysis, then start removing the 3-way interactions with the largest p-value until the MSE is approximately 0.05.