I think this is very broad yet specific question, 
1) we have to compare the test and reference product for multiple (related)parameters; and we have come across this tool of mCSRS
2) are these similar/superior to that reference scaled average BE approach?
A) Application of the modified chi-square ratio statistic in a stepwise procedure for cascade impactor equivalence testing.
most of the points are self explanatory. (I see that denominator of the calculation/equation is changed/modified ! wrt calculation of mCSRS!)
B) (broken link removed)
REFERENCE :-
Implementation of a Reference-Scaled Average Bioequivalence Approach for Highly Variable Generic Drug Products by the US Food and Drug Administration
1) we have to compare the test and reference product for multiple (related)parameters; and we have come across this tool of mCSRS
2) are these similar/superior to that reference scaled average BE approach?
A) Application of the modified chi-square ratio statistic in a stepwise procedure for cascade impactor equivalence testing.
most of the points are self explanatory. (I see that denominator of the calculation/equation is changed/modified ! wrt calculation of mCSRS!)
B) (broken link removed)
REFERENCE :-
Implementation of a Reference-Scaled Average Bioequivalence Approach for Highly Variable Generic Drug Products by the US Food and Drug Administration
