I would think so. Just moving the database to a new drive shouldn't affect the database. The part that will be important is that the program that uses the database for inputs and outputs is reconfigured to point to the new database location.
As Jennifer said, do a short run of labels. Then use your barcode scanner to read them. You'll be validating the database, the barcode scanner and the computer all at the same time. I would also include input, though - Make a new label, print it and then scan it.